Clinical Pearl Wednesday #41

Have a patient who is having difficulties losing weight?

Have you tried multiple “mainstream” methods such as diet/exercise, phentermine, Contrave, etc.?

Have you ever considered the use of peptide therapy? Peptides are short chains of amino acids that mimic a releasing hormone in the body.

One of my go to treatment options for weight loss in individuals who have low IGF-1 levels is Sermorelin.

Sermorelin is a growth hormone releasing hormone analogue. It induces a release of growth hormone from the pituitary gland.

Growth hormone causes lipolysis, therefore by utilizing a growth hormone secreting peptide to increase the endogenous levels of growth hormone, you can increase the body’s ability to burn that stubborn fat. It works great in many patients. It also carries a favorable safety profile.

Be aware though, this is considered an “off label” indication, as many things are in practice.

Dosing is straight forward. Typical starting doses are 100-200mcg nightly for 2-3 months, but this is patient specific and requires routine lab monitoring to monitor the IGF-1 and for adverse effects.

As with any advice, always use your own clinical judgement and do your own due diligence.

2 Responses

    1. HCG is bogus and nothing more than a placebo for weight loss. Sermorelin actually has an identifiable mechanism of action.

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