Clinical Pearl Wednesday #77

Disease Medicine Health Medication  - nastya_gepp / Pixabay

Considering putting a patient on Olmesartan for their hypertension? You might want to consider another option.

In 2013 the FDA required a label change for Olmesartan that includes celiac sprue like symptoms as a side effect.

Olmesartan-induced enteropathy mimics celiac disease both clinically and pathologically. Common symptoms include chronic diarrhea and weight loss.

Luckily, recovery or improvement of the Olmesartan induced mucosal inflammation can occur when the Olmesartan is discontinued!

So, be cautious about prescribing Olmesartan to your patients. If you have patients on this who are complaining of nausea, diarrhea, and weight loss, then consider Olmesartan as the cause in your differential.

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